PHOSPHORYLATION COUPLED WITH THE OXIDATION OF α-KETOGLUTARIC ACID
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چکیده
منابع مشابه
Oxidation of pyridine nucleotides coupled to phosphorylation.
Previous studies have indicated that the pentose cycle enzymes, including glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase, were localized in the soluble fraction of the homogenate isolated from kidney, liver, or heart tissue (1). Since reduced pyridine nucleotides are formed during the oxidation of G-6-P’ and 6-PGA, it was of interest to establish whether or not the reoxi...
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It has been established that at least two, and very likely three, phosphorylations are coupled to electron transport between reduced diphosphopyridine nucleotide and molecular oxygen in isolated mitochondria (l-3). However, very little is known of the location of these phosphorylating reactions along the chain of respiratory carriers. The point of greatest uncertainty and one of considerable im...
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An analysis of the dialyzable components of the pyruvic acid oxidation system of brain showed that in addition to cocarboxylase (thiamine pyrophosphate) (2), a C, dicarboxylic acid (2), and magnesium or manganese ions (3), both inorganic phosphate and “adenine nucleotide” (adenylic acid, adenosine triphosphate) (4) are required. The latter observation suggested that a cycle of phosphorylation i...
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WHEN a solution of pyridine-haemochromogen containing ascorbic acid is shaken in air, both substances undergo a coupled oxidation leading to verdohaemochromogen and dehydroascorbic acid [Karrer et al. 1933; Lemberg et al. 1938, 1, 2; cf. also Haurowitz,3 1937]. When haemoglobin and ascorbic acid are incubated in air at pH 7-2 and 380 a slower oxidation takes place giving choleglobin, a bile pig...
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The herbicidal actioIn of 2,4-dichlorophenoxyacetic acid (2,4-D) has been the subject of many investigations in the years sinice this compound was first demonstrated to be a plant toxicant. Almost as many possible mechanismiis for this toxicityhave been suggested. These includle depletioni of respiratory substrate, abnormal cellular proliferation, the production of toxic substances in response ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1949
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)56627-8